Is there a high probability of abnormal babies born at the age of 35?

With the development of social economy and the improvement of women's right of independent choice, more and more women choose to consider childbearing after the age of 35. However, compared with young mothers, is there a high probability of abnormal babies born at the age of 35? This article will elaborate on this issue from the aspects of age dependence, chromosome abnormalities, chronic diseases and embryonic development.

Age related

In biology, female eggs are formed from birth, and the number will not increase. With the growth of age, the quality and quantity of eggs will gradually decline, because of the influence of aging process. Therefore, women over 35 years old have a relatively high rate of abnormal babies.

A study conducted at the National Institute of Child Health and Human Development in the United States found that women over 35 years of age have a significantly reduced probability of having children, while the probability of chromosomal abnormalities is relatively increased. This is mainly due to abnormal chromosome segregation of eggs during the process of aging, which is a common biological phenomenon.

In addition, compared with young mothers, women over 35 are prone to complications during childbirth, such as hypertension and diabetes. These complications will not only increase the risk of pregnant women, but also adversely affect the development of the fetus.

Chromosomal abnormality

With the growth of age, the probability of chromosomal abnormalities in female eggs will gradually increase. After the age of 35, the probability of chromosome abnormalities will increase rapidly. Among them, Down syndrome is one of the common chromosomal abnormalities in women over 35 years old who give birth to abnormal babies.

Down syndrome is caused by the presence of three copies of chromosome 21, rather than the normal two copies. This abnormality can lead to mental retardation, heart disease and other physical development disorders. According to the statistics of the American Academy of Pediatrics, the probability of children with Down syndrome born to women over 35 years old is about 1 in 365, while the probability of children born to women under 30 years old is only 1 in 1500-2500.

In addition to Down syndrome, women over 35 years old are also prone to other chromosomal abnormalities in childbirth, such as unbalanced translocation of paternal and maternal origin. These chromosomal abnormalities may have a serious impact on the development and health of infants.

chronic disease

With the growth of age, women over 35 are more likely to suffer from some chronic diseases, such as hypertension, diabetes and heart disease. These chronic diseases will have a negative impact on the development of embryos, increasing the risk of infants suffering from congenital heart disease, neural tube defects and other abnormalities.

According to the data from the National Institutes of Health, pregnant women over 35 years old have a higher risk of hypertension and gestational diabetes during pregnancy. These diseases are not only harmful to the health of pregnant women, but also may have a negative impact on the development and health of the fetus.

embryonic development

With the growth of women's age, the development of embryos may be affected, increasing the probability of abnormal babies. A study conducted at Harvard Medical School in the United States found that women over 35 years old will have more chromosomal abnormalities in their eggs and embryos, leading to problems such as embryo termination and abortion.

In addition, women over 35 years of age may also have difficulty in conceiving because of the decline in ovarian function and the decrease in the number of eggs. This is also an important reason why women over 35 years old may need assisted reproductive technology (such as IVF) to give birth.

Summary

To sum up, the probability of abnormal babies born at 35 years old is relatively high. This is mainly because the increase in age will lead to the decline in the quality and quantity of female eggs, the increased risk of chromosomal abnormalities, and the emergence of chronic diseases and embryonic development problems. Therefore, for women over 35 years old, it is necessary to understand the relevant risks when preparing for childbirth, and take corresponding preventive measures under the guidance of doctors.