Males with malformations caused by elder childbearing
In modern society, with the progress of science and technology and the improvement of people's living standards, more and more men choose to postpone the childbearing age. However, the risks brought about by the elderly male childbearing have gradually attracted people's attention. The elder male childbearing may lead to the appearance of some abnormal babies. In the following, we will elaborate on the risks brought about by male elderly childbearing in terms of gene mutation, sperm quality decline, pregnant women factors and child health.
Gene mutation
There is a certain correlation between male aging fertility and gene mutation. Male sperm is the main carrier of genetic information, so gene mutation during male egg production is very important for offspring. With the growth of age, male sperm will gradually accumulate gene mutations, which may lead to chromosome abnormalities, genetic diseases dependent on mutant genes and other malformations. For example, Edison Hospital once pointed out in a study that the older the father is, the higher the risk of autism will be.
In addition, DNA damage in male sperm may also be related to gene mutation. It was found that the imbalance of DNA breakage and repair mechanism in male sperm will gradually increase with age, which may have a negative impact on embryonic development. Therefore, the elderly male fertility increases the proportion of gene mutations, thus increasing the risk of deformed children.
Decreased sperm quality
The aging of male fertility will also lead to the decline of sperm quality. With the increase of age, the quality of sperm in men will gradually decline, including changes in the number, vitality and morphology of sperm. A medical study shows that the sperm concentration and vitality of men over the age of 40 are significantly reduced. The decrease of sperm quality may lead to the decrease of fertilization ability, thus increasing the risk of abnormal infants.
In addition, the decline of sperm quality is also related to children's health problems. The study found that there was a certain correlation between the elderly male childbearing and the increased risk of children suffering from diseases, including autism, mental illness, etc. These problems may be related to the decrease of genome stability caused by the decrease of sperm quality. Therefore, the aging male fertility may cause the appearance of children with malformations through the decline of sperm quality.
Pregnancy factors
There is also a certain correlation between the abnormal babies caused by the elderly male childbearing and the pregnant women's factors. The age of pregnant women has an important impact on the health of the fetus. In fact, a large number of studies show that the increasing age of pregnant women will increase the probability of birth defects of children. Male elderly childbearing is often related to the age of pregnant women, and the combined effect of the two may increase the risk of deformed children.
In addition, the possibility of complications of pregnant women also exists in the elderly male childbirth. Pregnant women have a higher risk of complications such as gestational diabetes and hypertension in late pregnancy. These complications may indirectly lead to fetal growth restriction and increase the probability of deformed infants. Therefore, male elder childbearing may indirectly increase the risk of deformed children by influencing pregnant women.
Child health
The elderly male childbearing will also directly affect the health status of children. A study found that infants whose fathers are over 40 years old have a higher risk of congenital heart disease than fathers in other age groups. This may be due to the decline of sperm quality and gene mutation caused by the aging of male fertility, which will affect the heart development of embryos.
In addition, older men may also lead to an increased risk of genetic diseases in their offspring. Some genetic diseases, such as thalassemia and muscular dystrophy, will increase with the father's age. Therefore, the elderly childbearing of men increases the risk of children's disease.
Summary
The risks brought by the elderly male fertility are mainly reflected in gene mutation, sperm quality decline, maternal factors and child health. Older men tend to have more gene mutations in sperm, which increases the risk of chromosomal abnormalities and genetic diseases. In addition, sperm quality decline will also reduce fertility and increase the possibility of birth defects in children. In terms of pregnant women and children's health, older men may increase the risk of complications and affect embryonic development. Therefore, the elderly male fertility may lead to the emergence of a variety of malformations.
