Does hyperlipidemia affect the success rate of test tube infants?
IVF is a method of transferring fertilized eggs to the mother's uterus for pregnancy through assisted reproductive technology. However, high blood lipids may affect the success rate of IVF. Hyperlipidemia means that the concentration of fat in the blood exceeds the normal range. In this article, we will elaborate on the influence of high blood lipid on the success rate of IVF from several aspects.
1. Embryo development and implantation
Hyperlipidemia can lead to the decline of the quality of the fertilized eggs, thus affecting the development of the fertilized eggs. Once the egg quality is damaged, its fertilization ability to sperm and embryonic development potential will be reduced. In addition, hyperlipidemia may also lead to the abnormality of endometrium, which reduces the ability of embryo implantation into the uterus, thus affecting the success rate of IVF.
Studies have shown that high cholesterol and triglyceride levels are related to the quality of IVF embryos. A study from a famous hospital in Beijing found that the success rate of embryo development and implantation in patients with high blood lipids was significantly lower than that in patients with normal blood lipids. Therefore, the control of blood lipid level is essential for the embryonic development and implantation of IVF.
2. Effect of ovulation promoting drugs
In the process of IVF, ovulation promoting drugs are usually used to stimulate the ovary to produce more eggs. However, hyperlipidemia may reduce the effect of ovulation promoting drugs. Hyperlipidemia will interfere with the absorption and metabolism of drugs, reduce the bioavailability of drugs, and thus affect the quantity and quality of eggs.
A study conducted in a large reproductive hospital in Guangzhou found that after ovulation induction treatment, the egg production of patients with high blood lipids was significantly lower than that of patients with normal blood lipids. In addition, hyperlipidemia also increases the risk of complications during ovulation induction, such as ovarian hyperstimulation syndrome, which further affects the success rate of IVF.
3. Uterine environment
Hyperlipidemia may lead to abnormal changes in the uterine environment, affecting the implantation and pregnancy of embryos. The study found that the endometrial thickness of hyperlipidemia patients was significantly lower than that of normal hyperlipidemia patients. Thin endometrium will reduce the probability of embryo implantation, thus affecting the success rate of IVF.
In addition, hyperlipidemia may also increase the risk of abnormal angiogenesis in endometrium. These abnormal blood vessels may compete for the nutrition and oxygen needed by the embryo, further affecting the survival and development of the embryo. Therefore, maintaining a healthy uterine environment is critical to the success of IVF.
4. Risk of pregnancy complications
Hyperlipidemia also increases the risk of complications during IVF pregnancy, such as pregnancy induced hypertension, pregnancy induced diabetes, and pregnancy induced bleeding. These complications may not only affect the survival and development of embryos, but also increase the health risks of mothers and fetuses.
A study conducted in a famous obstetrics and gynecology hospital in Beijing found that the incidence of pregnancy complications in IVF patients with high blood lipids was significantly higher than that in patients with normal blood lipids. Therefore, reducing the level of blood lipids is essential to ensure the smooth progress of IVF pregnancy and embryonic health.
summary
In conclusion, hyperlipidemia is an important factor affecting the success rate of IVF. It not only affects the development and implantation of embryos, but also reduces the effect of ovulation promoting drugs, affects the uterine environment and increases the risk of pregnancy complications. Therefore, we emphasize that maintaining a good level of blood lipids is very important for the success of IVF. Patients can reduce blood lipids and improve the success rate of IVF through diet regulation, drug treatment and other ways.
