What is the relationship between the success rate of 40 year old IVF and age?
As a kind of assisted reproductive technology, IVF technology provides hope for many infertile couples. However, with the growth of age, women's fertility gradually declined, and the success rate of IVF for 40 year old women was low. The relationship between the success rate of 40 year old IVF and age will be described in detail from four aspects below.
1、 Decreased ovarian reserve function
The pregnancy ability of women is affected by the ovarian reserve function, and the ovarian reserve function of 40 year old women has gradually declined. The ovarian reserve function refers to the number and quality of eggs in the ovary. The number of eggs in a 40 year old woman decreases, and the quality will also be affected. As a result, the number of eggs collected by 40 year old women during IVF is relatively small, and the quality of eggs is not as good as that of young women, which reduces the success rate of IVF.
In addition to the decline of ovarian reserve function, age will also lead to low ovarian responsiveness, that is, the ovarian response to ovulation promoting drugs is weakened. This makes 40 year old women produce fewer eggs during IVF, further reducing the success rate.
2、 Decreased egg mass
With the growth of age, the egg quality of 40 year old women began to decline. The decrease of egg mass is mainly manifested by the increase of chromosome abnormalities, such as common chromosome number abnormalities or structural abnormalities. These abnormal eggs are easy to lead to problems in the development of fertilized eggs, resulting in a decline in the quality of embryos. Embryo quality is closely related to the success rate of IVF. The weakening of egg quality will lead to the reduction of embryo implantation rate and pregnancy rate, thus reducing the success rate of IVF for 40 year old women.
3、 Increased risk of spontaneous abortion
The risk of spontaneous abortion also increased significantly after 40 year old women had IVF. This is closely related to the weakening of egg quality and the increase of chromosome abnormalities. 40 year old women have a high probability of abnormal egg development and fertilization, and the embryos formed after fertilization are also prone to problems. When an embryo with abnormal development is implanted, it often fails to develop normally, which easily leads to spontaneous abortion.
In addition, because the uterine function gradually decreases with age, the blood supply and nutrition supply of endometrium in 40 year old female IVF will decrease accordingly, which also increases the risk of spontaneous abortion.
4、 Higher requirements for health
When IVF was carried out at the age of 40, women's physical conditions were already relatively poor, and the probability of suffering from chronic diseases also increased accordingly. For example, 40 year old women are more likely to suffer from chronic diseases such as hypertension and diabetes, which will have a negative impact on the success rate of IVF.
In addition, the body of a 40 year old woman is also less adaptable to hormonal changes, and is more sensitive to the side effects of ovulation promoting drugs. This increases the risk of IVF process to some extent.
Summary
In conclusion, the success rate of IVF for women aged 40 is low. The main reasons include decreased ovarian reserve function, weakened egg quality, increased risk of spontaneous abortion and higher requirements for health. Therefore, older women should know and consider their fertility and the success rate of IVF in advance, and make a comprehensive decision.
