Problems and risks in the success rate of 42 year old IVF infants
IVF technology has brought hope to many infertile couples, but for older women, there are some problems and risks in the success rate. The following is detailed from four aspects.
1. Egg quality decline
As women grow older, the quality of their eggs will gradually decline. The number and quality of eggs of women around the age of 40 have significantly decreased, thus affecting the success rate of IVF. The decrease of egg quality will lead to the decrease of fertilization rate and implantation rate, and increase the risk of abortion.
In addition, due to the decline in egg quality, it is also possible that the use of higher doses of hormones to stimulate the ovary may not be able to obtain enough eggs in quantity and quality. This will increase the number of treatment cycles and increase the burden and risk on women's bodies.
In addition, when older women receive assisted reproductive technology, due to the decline of ovarian reserve function, they often respond poorly to gonadotropin treatment, and are prone to ovarian hyperstimulation syndrome, which poses a threat to women's health.
2. High frequency chromosomal abnormalities
The probability of chromosomal abnormalities in female eggs increases with age. Chromosome abnormalities may lead to embryonic dysplasia, abortion or birth of babies with chromosomal abnormalities. For women over 42 years old, the risk of chromosomal abnormalities in embryos is very high.
In order to select embryos with normal chromosomes, embryo chromosome screening or PGD technology is required, which will increase the overall cost and operational risk of IVF.
In addition, due to the high risk of chromosomal abnormalities, women over 42 years old may need multiple pregnancies during IVF, which also increases the challenge and risk of pregnant healthy babies.
3. Increase of pregnancy complications
Older women are at greater risk of complications during pregnancy. These complications include gestational diabetes, hypertension, premature delivery and fetal development problems. The decrease in the success rate of IVF may be related to the increase of these complications.
Gestational diabetes may have adverse effects on fetal development, hypertension may increase the risk of maternal and infant death, and premature delivery and fetal development problems may affect the health of infants.
Therefore, women over 42 years of age should receive a comprehensive physical examination and assessment before IVF, so as to understand their own physical condition and pregnancy risk, and make a wise decision.
4. Psychological and economic pressure
The IVF process not only has certain risks to health, but also brings psychological and economic pressure to couples.
Older couples may experience multiple IVF cycles, and the failure and waiting between cycles may cause a heavy psychological burden on the couple. At the same time, due to the high cost of IVF, some families may face economic pressure.
Therefore, before considering IVF, couples over 42 years old should fully understand the risks and costs of the whole process, and at the same time make psychological preparations to better cope with possible difficulties and pressures.
Summary
There are some problems and risks in the success rate of 42 year old IVF infants. The decline in egg quality and the increase in the frequency of chromosomal abnormalities in women at this age increase the risk of decreased fertilization and implantation rates and abnormal embryonic development. At the same time, the risk of pregnancy complications also increases, which may affect the health of mothers and infants. The psychological and economic pressure during IVF should also be considered. Therefore, couples over 42 years old need to comprehensively assess the risks and costs and be prepared before considering IVF.
