Effect of premature ovarian failure on the success rate of test tube infants
Premature ovarian failure (POF) refers to the decline of ovarian function before the age of 30, which leads to irregular or stopped menstruation, poor follicular development, and often accompanied by infertility. With the development of IVF technology, many women with ovarian dysfunction choose IVF to realize their reproductive dreams. However, premature ovarian failure will directly affect the success rate of IVF. The following is a detailed description of the impact of premature ovarian failure on the success rate of IVF from four aspects: ovarian hormone level, egg quality, embryo transfer success rate and pregnancy success rate.
1. Ovarian hormone level
Premature ovarian failure can lead to abnormal levels of ovarian hormones, including decreased secretion of estrogen and progesterone. The lack of estrogen may lead to normal thickening of endometrium and affect embryo implantation. The decrease of progesterone may lead to the failure of embryo development in uterus and increase the risk of early abortion. Therefore, in the process of IVF, women with premature ovarian failure need to adjust hormone levels through exogenous hormone therapy to improve the success rate of IVF.
However, because premature ovarian failure has led to a decline in the number and quality of follicles, the effect of hormone therapy is limited. Some women may need high doses of hormone to reach normal levels, which increases the risk and side effects of hormone therapy. Therefore, in the case of premature ovarian failure, the success rate of IVF is also limited by hormone therapy.
2. Egg quality
The decrease in the number and quality of follicles is one of the main characteristics of premature ovarian failure. Follicular dysplasia can lead to a decline in egg quality, including an increased risk of chromosomal aberrations and genetic mutations. These abnormal eggs often fail to develop into embryos or abnormal embryos during fertilization, which increases the risk of transfer failure.
The decrease of egg quality will also affect embryo implantation rate and pregnancy rate. Research shows that the decline of egg quality in women with premature ovarian failure is closely related to the reduction of embryo implantation rate and pregnancy rate. Therefore, women with premature ovarian failure need to improve the success rate by selecting high-quality eggs in the process of IVF. This may require multiple egg retrieval and IVF cycles to obtain sufficient quantity and quality of eggs.
3. Success rate of embryo transfer
Embryo transfer is one of the most critical links in the process of IVF. Women with premature ovarian failure may obtain fewer embryos due to the decline in the number and quality of follicles. This limits the choice in the process of embryo transfer and increases the risk of transfer failure.
At the same time, women with premature ovarian failure may need to carry out multiple IVF cycles to obtain sufficient quantity and quality of embryos. This increases the time and economic cost of the whole IVF process. Other factors that may exist in the process of multiple IVF, such as endometrial status and transfer technology, may also affect the success rate of embryo transfer.
4. Pregnancy success rate
The decrease of egg quality and the success rate of embryo transfer in women with premature ovarian failure directly affects the success rate of IVF pregnancy. Research shows that women with premature ovarian failure have a lower pregnancy rate and a higher abortion rate. Age is also an important factor affecting the success rate of pregnancy.
Therefore, women with premature ovarian failure need to fully understand the impact of ovarian function decline on the success rate during IVF, and formulate appropriate treatment plans under the guidance of doctors. At the same time, women with premature ovarian failure should adopt an active lifestyle, such as maintaining good nutrition, reasonable exercise and reducing pressure, to improve the success rate of IVF.
Summary
Premature ovarian failure has a significant impact on the success rate of IVF. The abnormal level of ovarian hormone, the decline of egg quality, the reduction of the success rate of embryo transfer and the reduction of the success rate of pregnancy are all important factors for premature ovarian failure to affect the success rate of IVF. Therefore, women with premature ovarian failure need to fully understand the characteristics of ovarian function decline during IVF and seek guidance and treatment from professional doctors. In addition, an active lifestyle also helps to improve the success rate of IVF.
