Does high prolactin affect the success rate of IVF?

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Does high prolactin affect the success rate of IVF?

IVF technology is a kind of assisted reproductive technology, which aims to help couples who cannot conceive naturally achieve their reproductive aspirations. However, high prolactin is a common endocrine disorder, which may have a certain impact on the success rate of IVF. The potential impact of high prolactin on the success rate of IVF will be discussed in detail from several aspects.

Influence ovulation and egg quality

High prolactin may affect female ovulation. The increased level of prolactin will inhibit the development of follicles and the ovulation process, leading to abnormal ovulation or anovulation. As a result, women cannot provide enough normal eggs for IVF operation.

In addition, high prolactin can also lead to the decline of egg quality. Egg quality is one of the important factors for successful pregnancy. Eggs with normal morphology and karyotype are more likely to develop into healthy embryos. Studies have found that women with high prolactin tend to have poor egg quality, which will reduce the success rate of IVF.

In addition, high prolactin may also increase the risk of ovarian cysts, especially those in the luteal phase. The presence of cysts may interfere with ovarian function and further affect the success rate of IVF.

Influence endometrial preparation and implantation

High prolactin will affect the preparation of endometrium, and then affect the implantation of embryos. Endometrium is the place for embryo implantation. High prolactin may cause instability, atrophy or ischemia of endometrium, thus reducing the possibility of implantation. If the embryo cannot be successfully implanted, the success rate of IVF will be affected.

Affect luteal function

The corpus luteum is a temporary endocrine organ formed by the ovary after ovulation. High prolactin may affect the function of the corpus luteum, leading to the insufficiency of corpus luteum, that is, the decrease of progesterone level. Progesterone plays a role in maintaining the stability of the intrauterine environment in early pregnancy, and low progesterone levels will increase the risk of pregnancy.

In addition, high prolactin may also cause premature termination of early pregnancy, that is, abortion. Luteal insufficiency and abortion will reduce the success rate of IVF.

Effect of ovulation promoting drugs

In order to stimulate ovarian development and increase the number of eggs, ovulation promoting drugs are often used in IVF. However, high prolactin may reduce the efficacy of ovulation promoting drugs and reduce the ovarian response to hormones. This will affect the development of follicles and the quality of eggs, thereby reducing the success rate of IVF.

In conclusion, high prolactin has a significant impact on the success rate of IVF. It may not only affect ovulation and egg quality, but also affect endometrial preparation, implantation, luteal function and the efficacy of ovulation promoting drugs. Before IVF, it is recommended to conduct comprehensive examination and treatment in formal medical institutions to improve the success rate of IVF.