Causes of adenomyosis in test tube infants
In vitro adenomyosis is a disease caused by various factors affecting oocytes and sperm in vitro. The causes of adenomyosis in IVF are described in detail from four aspects: chromosome abnormality, gene mutation, endocrine disorder and other factors.
Chromosomal abnormality
Chromosome abnormality is one of the main causes of adenomyosis in IVF. First, in the process of oocyte and sperm combination, chromosome imbalance collision will lead to chromosome loss or duplication. Secondly, parents with chromosomal abnormalities lead to chromosomal abnormalities in the embryo during the genetic process. Finally, chromosome abnormalities of recipient sperm or donor sperm will also lead to chromosome loss or abnormality. Therefore, chromosome abnormality is an important cause of adenomyosis in IVF.
Chromosome abnormality can be divided into structural abnormality and numerical abnormality. Common structural abnormalities include inversion, insertion, deletion and duplication, which can lead to chromosome abnormalities of sperm or egg. The abnormal number mainly refers to the abnormal number of chromosomes, such as trisomy syndrome. The formation of these abnormalities will lead to fertility problems of IVF.
Gene mutation
Gene mutation is another important cause of adenomyosis in IVF. Gene mutation mainly refers to changes in gene sequence. These changes may lead to abnormal expression of genes or impaired function. Gene mutation can be inherited, that is, abnormal genes in parents lead to embryonic gene mutation; It can also be acquired postnatal, such as gene mutation caused by environmental factors in vitro. Gene mutation has an important impact on the development and function of the reproductive system, leading to the occurrence of adenomyosis in IVF.
For example, a common gene mutation that causes adenomyosis is cystic fibrosis. Cystic fibrosis is an autosomal recessive disease caused by mutations in the CFTR gene, which affects the normal development and function during development.
Endocrine disorder
Endocrine disorder is another important cause of adenomyosis in IVF. The endocrine system is an important regulatory system of the human body, which directly or indirectly participates in regulating the development and function of the reproductive system. Endocrine imbalance may lead to abnormal follicular development and irregular ovulation cycle, thus affecting fertility. Common endocrine disorders caused by adenomyosis in test tube infants include polycystic ovary syndrome and thyroid dysfunction.
Polycystic ovary syndrome (PCOS) is a common disease caused by endocrine disorders, which leads to abnormal maturation and discharge of follicles in the ovary. In the process of IVF, this will lead to the failure of follicles to be obtained and fertilized, thus affecting fertility.
Other factors
In addition to chromosome abnormalities, gene mutations and endocrine disorders, there are other factors that may lead to the formation of adenomyosis in IVF. These factors include: uterine cavity malformation, endometriosis, chronic pelvic inflammation and tubal obstruction. These factors affect the structure and function of the female reproductive system, leading to the occurrence of adenomyosis in IVF.
Summary
Adenomyosis in IVF is caused by chromosome abnormalities, gene mutations, endocrine disorders and other factors. Chromosome abnormalities include structural and numerical abnormalities. Gene mutations may be inherited or acquired. Endocrine disorders may cause ovarian dysfunction, while other factors such as uterine cavity abnormalities and tubal obstruction may also lead to adenomyosis in test tube infants. Understanding these causes will help us better understand the pathogenesis of adenomyosis in IVF and take appropriate treatment measures to improve the prognosis of the disease.
