Population suitable for PGD IVF
PGD (Preimplantation Genetic Diagnosis) test tube baby technology is a kind of technology that uses embryo gene testing to screen embryos with specific genetic diseases during in vitro fertilization, and then transfers disease-free embryos to the maternal uterus to reduce the genetic risk of some genetic diseases. PGD test tube baby technology has certain feasibility and application prospects in the applicable population.
Applicable population I: carriers of monogenic genetic diseases
Single gene genetic disease is a kind of hereditary disease caused by gene mutation, such as cystic fibrosis, thalassemia, etc. Both spouses are carriers, and each pregnancy will have a half chance to pass the embryo with the mutation gene to the offspring. PGD technology can screen healthy embryos for implantation through embryo gene detection, and reduce the risk of related diseases.
In addition, for some male patients with monogenic disease, the particularity of the disease may affect their reproductive function, so PGD IVF technology has also become an important means for them to achieve their reproductive aspirations.
It is worth mentioning that hospitals and research institutions around the world, such as Massachusetts General Hospital and Harvard Medical School in the United States, and King's College London in the United Kingdom, have accumulated rich experience and research results in the application of PGD technology for single gene diseases.
Applicable group II: recurrent abortion
Recurrent abortion refers to women who have suffered from different embryo implantation failures or miscarriages during pregnancy for more than two consecutive times. This kind of situation may be because the embryo carries a variety of chromosome abnormalities, structural abnormalities or other genetic diseases, resulting in the embryo can not develop normally.
PGD test tube baby technology can select healthy embryos through chromosome structure of embryos and genetic detection of genetic diseases, improve the success rate of pregnancy and reduce the risk of abortion. Many domestic and foreign reproductive hospitals, such as Peking Union Medical College Hospital in China and Mayo Clinic in the United States, have made some research achievements in this regard.
Applicable group III: older women
Female age is one of the important factors affecting fertility. With the increase of women's age, the quality and quantity of eggs will gradually decline, leading to weakened fertility, and the probability of chromosomal abnormalities will also increase. PGD test tube baby technology can conduct gene detection on eggs, screen out normal embryos, and improve the probability of successful pregnancy and pregnancy.
For example, the University of Toronto Fertility Medical Center in Canada used PGD technology to help older women successfully achieve pregnancy and childbirth.
Applicable population 4: healthy carriers want to choose the sex of embryos
Under certain cultural and family backgrounds, couples may have a preference for choosing the sex of embryos. PGD test tube baby technology can screen the embryos carrying the desired sex gene through embryo gene detection for transfer, so as to achieve the purpose of selecting the embryo sex.
In conclusion, PGD test tube baby technology is applicable to people with single gene genetic disease carriers, recurrent miscarriages, older women and healthy carriers who want to choose the sex of embryos. The development of this technology not only provides a new choice for solving some genetic diseases, but also provides an effective solution for fertility difficulties in some different situations.
