How does intrauterine adhesion affect the success rate of IVF implantation?
IVF technology is one of the important ways to help infertile couples realize their reproductive dreams, but intrauterine adhesion has become one of the common factors affecting the success rate of implantation. It refers to the adhesion of endometrium to the uterine wall or the surface of other organs, which will reduce the smoothness of endometrium and affect the implantation of embryos. The following will discuss in detail the influence of intrauterine adhesion on the success rate of IVF implantation from the perspective of uterine cavity shape, endometrial quality, embryo quality and surgical treatment.
Morphology of uterine cavity
The abnormal shape of uterine cavity is one of the important manifestations of uterine cavity adhesion, such as endometrial cardiac stenosis, endometrial local thickening, etc. These abnormalities will lead to insufficient nutrition supply of endometrium and affect embryo implantation. A study by Peking Union Medical College Hospital showed that there was a negative correlation between abnormal uterine cavity morphology and IVF implantation rate. The implantation rate of patients with normal morphology was significantly higher than that of patients with abnormal morphology.
In addition, abnormal uterine cavity morphology also increases the risk of embryo damage during transport. The adhered uterine cavity will increase the contact area of the embryo, leading to an increase in the retention time of the embryo in the uterine cavity, which will adversely affect the development of the embryo. Therefore, the abnormal shape of uterine cavity directly affects the success rate of embryo implantation.
Endometrial mass
Uterine cavity adhesion will affect the quality of endometrium, reduce the number of glands and secretion function of endometrium. The decrease of endometrial quality will affect the preparation of embryo implantation and weaken the adsorption capacity of endometrium to embryo. The study of Ruijin Hospital affiliated to Shanghai Jiaotong University School of Medicine found that there was a significant difference in endometrial thickness between the adhesion group and the normal group, and the endometrial thickness of the adhesion group was significantly reduced.
The decrease of endometrial quality will also lead to the decrease of endometrial blood flow and the reduction of oxygen and nutrition provided to the embryo. This will hinder the implantation of embryos, thus reducing the success rate of implantation. Therefore, the adverse effect of intrauterine adhesions on endometrial quality is an important factor affecting the success rate of implantation.
Embryonic quality
Intrauterine adhesions can affect the quality of embryos and lead to abnormal embryonic development. During the development of the embryo in the uterine cavity, it is greatly affected by the uterine cavity environment. In patients with intrauterine adhesions, the quality of their embryos is generally poor due to the decline in endometrial quality and changes in the internal environment of the uterus. A study conducted by the First Hospital of Peking University showed that the embryo quality of the group with intrauterine adhesions was significantly lower than that of the normal group.
The quality of embryo is one of the important indicators of successful implantation. The decrease of embryo quality will lead to the decrease of embryo implantation ability, thus reducing the success rate of IVF implantation. Therefore, the influence of intrauterine adhesions on embryo quality directly affects the success rate of implantation.
surgical treatment
Patients with intrauterine adhesions can improve the uterine cavity environment through surgical treatment, and improve the success rate of IVF implantation. The commonly used surgical treatment methods include hysteroscopic resection of adhesive tissue and uterine cavity separation. These operations can effectively restore the shape of uterine cavity and the quality of endometrium, improve the quality of embryos, and improve the success rate of implantation.
A study conducted by Tianjin Obstetrics and Gynecology Hospital showed that after surgery, the implantation rate of test tube babies in the intrauterine adhesions group increased significantly, reaching the level of the normal group. Surgical treatment can not only improve the condition of uterine cavity adhesion, but also improve the endometrial status and embryo quality, thus improving the success rate of implantation.
Summary
It can be seen from the above discussion that intrauterine adhesion has a significant impact on the success rate of IVF implantation. The abnormal shape of uterine cavity, the decline of endometrial quality, the decline of embryo quality and other factors will lead to the decline of IVF implantation ability. However, surgical treatment can improve these conditions and improve the success rate of IVF implantation. Therefore, for infertile couples with intrauterine adhesions, early detection and timely treatment are the key to improve the success rate of implantation.
