The influence of intrauterine adhesion on the success rate of IVF
Uterine cavity adhesion refers to abnormal adhesion of endometrium and formation of adhesions, which seriously affects the possibility of pregnancy and successful IVF. It will have a variety of effects on the success rate of IVF, which will be described in detail in the following four aspects: embryo implantation, embryo development, abortion risk and implantation difficulties.
1. Embryo implantation
Uterine cavity adhesion will narrow the uterine cavity, fix the position of embryo implantation, and lead to difficulties in the implantation process. First, uterine cavity adhesion may make the endometrium irregular, making it difficult for the embryo to find a suitable implantation site, thus affecting the embryo implantation on the endometrium. Secondly, uterine cavity adhesion may also affect the close combination between the embryo and the endometrium, making the embryo vulnerable to extrusion during implantation, increasing the friction between the embryo and the endometrium, and increasing the possibility of embryo shedding or damage during implantation.
In addition, intrauterine adhesions can also lead to instability of the embryo position, making it easy for the embryo to shift or fall after implantation. This may increase the rate of embryo loss during IVF transfer and reduce the possibility of success.
2. Embryonic development
Uterine cavity adhesion will affect the normal development of the embryo. The development of the embryo in the uterine cavity is affected by the surrounding environment. The uterine cavity adhesion will change the characteristics of the endometrium, affect the nutrition supply of the endometrium to the embryo and the excretion of metabolites, thus adversely affecting the normal development of the embryo.
In addition, intrauterine adhesions may also hinder the movement of embryos in the uterine cavity, limiting their development space. This restricts the growth and development of embryos in the uterine cavity, increases the risk of abnormal embryonic morphology and function, and reduces the possibility of successful pregnancy.
3. Risk of abortion
Uterine cavity adhesion causes irregular endometrium and impeded blood flow, which will increase the risk of abortion. The embryo needs good blood supply after implantation in the endometrium to complete the establishment and maintenance of pregnancy. Uterine cavity adhesion restricts the circulation of blood in the endometrium, making the blood supply of the endometrium insufficient, affecting the nutrition supply and oxygen intake of the embryo.
In addition, intrauterine adhesions may also cause endometrial degeneration or ischemia, increasing the risk of abnormal embryonic development, growth cessation and abortion. Therefore, after IVF transplantation, patients with intrauterine adhesions need to closely observe pregnancy for monitoring and intervention, so as to timely identify and deal with the risk of abortion.
4. Implantation difficulty
Uterine cavity adhesion will change the shape of endometrium, increasing the difficulty of IVF implantation after transplantation. Uterine cavity adhesion makes the endometrium uneven and irregular, and the embryo is easy to combine with it and unstable. The embryo has a certain selectivity for the endometrium suitable for implantation, and the uneven endometrial surface will increase the difficulty and possibility of failure of the embryo to combine with it.
In addition, intrauterine adhesions may also cause dysfunction of the endometrium, reduce the expression of adhesion proteins and growth factors, and thus reduce the success rate of IVF implantation on the endometrium.
Summary
Uterine cavity adhesion has various effects on the success rate of IVF. It makes embryo implantation difficult and increases the risk of instability of embryo position; It affects the normal development of embryos and increases the risk of abnormal embryo morphology and function; It increases the risk of abortion and affects the nutrition supply and oxygen intake of embryos; It increases the difficulty of IVF implantation after transplantation. For patients with intrauterine adhesions, appropriate treatment measures should be taken, such as separation of intrauterine adhesions or auxiliary measures, to improve the success rate of IVF.
