How Heparin Promotes IVF Successful Pregnancy
IVF is a kind of assisted reproductive technology, which can help couples who cannot conceive naturally realize their desire to conceive. Heparin, as a commonly used drug, has been widely used in the process of in vitro fertilization embryo transfer (IVF-ET) to improve the success rate of IVF. In the following article, we will introduce how heparin promotes IVF pregnancy from several aspects.
1. Promote embryo implantation
Heparin has anticoagulant and anti-inflammatory effects, which can reduce the degree of blood coagulation and prevent embryos from being affected by thrombosis when they are implanted in the uterus. Heparin can also reduce the inflammatory reaction of endometrium and improve the probability of embryo implantation in uterus. In addition, heparin also improves the blood circulation in the uterus and increases the supply of nutrients and oxygen for embryo implantation.
Some studies have shown that heparin can significantly increase the pregnancy rate and clinical pregnancy rate during IVF-ET. For example, a hospital study showed that the pregnancy rate of IVF patients receiving heparin treatment increased from 38% to 55%.
2. Reduce natural killer cell activity
Natural killer cells (NK cells) are a kind of immune cells that can recognize and kill abnormal embryos. Heparin can improve the success rate of IVF by inhibiting the activity of NK cells and reducing their attack on embryos. The research of a hospital shows that heparin can significantly reduce the content of NK cells and improve the implantation rate and clinical pregnancy rate.
3. Improve the intrauterine environment
Heparin can improve the intrauterine environment and increase the success rate of implantation and pregnancy. Studies have found that heparin can increase the thickness of endometrium and promote its absorption of embryos. In addition, heparin can also reduce the immune response of endometrium, reduce the infiltration of immune cells, thus improving the implantation rate of embryos.
A study on IVF patients in a hospital showed that the endometrial thickness of patients treated with heparin increased significantly, and the implantation rate of embryos also increased significantly.
4. Reduce the risk of early abortion
Early abortion is one of the common complications in IVF. Heparin can reduce the risk of early abortion in many ways. First, heparin can reduce the risk of early abortion due to thrombosis by reducing the formation of thrombus and improving blood circulation. Secondly, heparin can reduce the risk of early abortion caused by immune reaction of embryos by reducing the inflammatory reaction of endometrium.
Some studies have shown that the early abortion rate of IVF patients treated with heparin is significantly reduced. For example, a study in a hospital showed that among patients receiving heparin treatment, the early abortion rate decreased from 27% to 15%.
Summary
Heparin plays an important role in the process of IVF, which can promote embryo implantation, reduce the activity of natural killer cells, improve the intrauterine environment, and reduce the risk of early abortion. Through the use of heparin, the success rate of IVF has been significantly improved. However, it should be noted that the use of heparin should be carried out under the guidance of doctors, because the choice of dosage and use time is crucial to its effect.
