New technical progress of IVF test items
The development of IVF technology has enabled many infertile couples to realize their reproductive dreams. With the continuous progress of science and technology, the inspection items of IVF are also developing and improving. This article will introduce the new technological progress of IVF test from aspects of embryo screening, genetic testing, embryo evaluation and fetal monitoring.
Embryo screening
Embryo screening is an important step before IVF to exclude genetic diseases and chromosomal abnormalities carried by embryos. Traditional embryo screening usually uses genotype analysis and chromosome analysis, which is not only time-consuming and laborious, but also has a high risk of damage to embryos.
In recent years, a new generation of gene sequencing technology has emerged, such as whole genome sequencing and whole exome sequencing, which can comprehensively detect the genes of embryos in a short time. These technologies can detect not only common single gene genetic diseases, but also rare and complex genetic diseases, greatly improving the accuracy and efficiency of embryo screening.
In addition, there are some non-invasive embryo screening techniques that can be carried out without harming the embryo, such as amniocentesis and chorionic villus sampling. The emergence of these new technologies makes embryo screening more safe and reliable.
Genetic testing
In addition to checking the risk of genetic diseases in embryos, parents of IVF also need to carry out genetic testing to know whether they carry genes of genetic diseases.
Traditional genetic testing is mainly carried out through gene mutation screening, family investigation and family history records. However, these methods have some limitations and cannot provide accurate detection for complex genetic diseases.
In recent years, the development of gene sequencing technology provides more choices for genetic detection. Whole genome sequencing and whole exome sequencing can detect a large number of genes at the same time, providing more accurate information for genetic detection and more comprehensive screening of complex genetic diseases.
Embryo evaluation
Embryo evaluation is one of the important determinants of the success rate of IVF. Traditional embryo evaluation mainly relies on morphological observation, but this method has subjectivity and inaccuracy problems.
Now, new technologies in embryo evaluation mainly include time series analysis and genomics evaluation. Time continuous analysis evaluates embryo quality by monitoring parameters such as embryo development and cell proliferation rate.
Genomics assessment assesses the potential development ability of embryos through gene expression profiles and DNA methylation status of genomes. These new technologies can effectively improve the accuracy and reliability of embryo assessment, help doctors select the most promising embryos for transplantation, and improve the success rate of IVF.
Fetal monitoring
After the successful pregnancy of IVF, the health of the fetus also needs to be monitored. Traditional fetal monitoring is mainly carried out by ultrasonic detection, amniocentesis and villus sampling, but these methods have certain risks to both mother and fetus.
In recent years, new technologies have emerged, such as non-invasive prenatal genomic testing (NIPT) and fetal plasma DNA detection. These methods can not only reduce the risk to the mother and fetus, but also detect the abnormalities of the fetus earlier by analyzing the fetal genetic material in the maternal blood to assess the fetal health status.
To sum up, the technology of IVF test program is developing continuously, and there are many new developments in embryo screening, genetic testing, embryo evaluation and fetal monitoring. The application of these new technologies makes IVF more safe and reliable, and provides more hope for infertile couples to realize their reproductive dreams.
