Drug Prevention of Fetal Arrest in Third Generation IVF
The third generation of IVF is a new technology to obtain fertility opportunities, but fetal arrest is still a common problem in the process of embryo transfer. Fetal arrest refers to the failure of embryo implantation or development stagnation after transplantation. In order to solve this problem, researchers have been looking for drugs to prevent fetal arrest. This article will elaborate on the drug prevention of the third generation IVF from the following aspects.
1. Causes of tire stop
To understand the prevention of tire stoppage, it is necessary to first understand the reasons for tire stoppage. The causes of fetal arrest include embryo quality problems, endometrial abnormalities, immune system problems, and so on. Embryo quality problems are the most common causes, including chromosome abnormalities, embryonic dysplasia, etc. Abnormal endometrium, such as thin or unhealthy endometrium, can affect embryo implantation. The immune system problem refers to the immune response of the immune system to the embryo, which prevents the embryo implantation and development. Only by understanding these reasons can we carry out targeted drug prevention.
2. Drugs to prevent fetal arrest
At present, some drugs are used to prevent fetal arrest. For example, low molecular weight heparin can improve endometrial blood flow and promote embryo implantation. Estrogen can regulate the thickness and health of endometrium and improve the success rate of embryo implantation. Glucocorticoids can regulate the immune system and avoid adverse reactions of the immune system to embryos. The use of these drugs needs to be carried out under the guidance of doctors, because each patient's situation is different, and individual treatment plans are needed.
In addition, some adjuvant drugs can also be used to prevent fetal arrest. For example, vitamin E, vitamin C and folic acid can provide nutrients needed for embryonic development and increase the chances of embryo implantation. Anticoagulants can prevent the formation of blood clots and ensure the nutrition supply of embryos in the endometrium. These adjuvant drugs can be used as adjuvant treatment under the advice of doctors.
3. Effectiveness and side effects of drug prevention
For the effectiveness of drugs in preventing fetal arrest, the research results are different. Some studies have shown that the use of low molecular weight heparin can indeed improve the success rate of embryo implantation and pregnancy, but some studies have also shown that the use of low molecular weight heparin has no obvious improvement effect on embryo suspension of embryos with chromosome abnormalities. For other drugs, there is not enough evidence to prove their effectiveness.
Drugs to prevent fetal arrest also have some side effects. For example, low molecular weight heparin may increase the risk of bleeding; Estrogen may cause breast hyperplasia, edema and other side effects; Glucocorticoids may cause immunosuppression and osteoporosis. Therefore, when using drugs to prevent fetal arrest, doctors need to consider patients' conditions and risks comprehensively and develop individualized treatment plans.
4. Hospital examples and summary
Beijing Shengde Childcare Hospital is one of the leading three generations of IVF diagnostic and therapeutic hospitals in China. The hospital has carried out a number of studies to find ways to prevent fetal arrest with drugs. Through clinical practice and academic research, they constantly optimize the treatment plan of drug prevention, and improve the success rate of embryo implantation and pregnancy.
To sum up, drug prevention of fetal arrest plays a certain role in the third generation of IVF. For embryo quality problems, endometrial abnormalities and immune system problems, drugs can provide targeted treatment. However, the effectiveness and side effects of drug prevention still need more research to verify. When choosing drugs to prevent fetal arrest, individualized treatment plans should be formulated according to the specific conditions of each patient.
