Does HCG value change of test tube infants reflect progesterone level?
In vitro fertilization (IVF) is a method of assisted reproduction, which is often used to treat infertility. In the process of IVF, the monitoring of progesterone level is very important, which is usually reflected by the HCG value. However, does the change of HCG value really reflect the level of progesterone? This article will elaborate on the background knowledge, the relationship between HCG and progesterone, experimental evidence and hospital experience in order to comprehensively answer this question.
background knowledge
Before we know whether the change of HCG value reflects the progesterone level, we first need to understand the basic knowledge of IVF process and related hormones. In IVF, ovulation guidance drugs usually stimulate the ovary to produce multiple follicles. After egg collection in the ovary, sperm and egg are fertilized in vitro to form a fertilized egg. Subsequently, the fertilized egg is transferred back to the mother's uterus in order to develop into an embryo.
Relationship between HCG value and progesterone
HCG is the abbreviation of human chorionic gonadotropin, also known as pregnancy hormone. After implantation of the fertilized egg, the embryo will produce HCG. After 4-5 weeks of pregnancy, the placenta begins to produce progesterone. The main role of progesterone is to maintain pregnancy and promote embryonic development.
Therefore, the production of HCG is related to the production of progesterone. HCG can stimulate corpus luteum to produce progesterone, and the level of progesterone is also positively correlated with the level of HCG. Therefore, the secretion of progesterone can be indirectly understood by monitoring the change of HCG value.
Experimental evidence
Several studies have explored the relationship between HCG value and progesterone level. A study published in the Journal of Reproductive Endocrinology found that HCG value and progesterone level showed a consistent growth trend in the early pregnancy after implantation of fertilized eggs.
Another study observed changes in HCG values during the IVF cycle and compared them with daily progesterone levels. The results showed that the HCG value was consistent with the progesterone level to a large extent, and the increase of HCG value corresponded to the increase of progesterone level.
These results indicate that the change of HCG value can indirectly reflect the change of progesterone level in the process of IVF.
Hospital experience
Many IVF hospitals have also summarized some experience through clinical practice. Taking a real hospital as an example, the routine monitoring of HCG and progesterone levels in the process of IVF was carried out and compared. Through the observation of a large number of cases, the hospital found that there was a certain correlation between the change of HCG value and the level of progesterone.
The experience of the hospital further strengthened the view that the change of HCG value reflects the level of progesterone. However, the hospital also pointed out that HCG value as an indicator of progesterone level is not absolutely accurate, and it needs to be combined with other clinical indicators for comprehensive judgment.
Summary
To sum up, changes in HCG values reflect progesterone levels to some extent. HCG can stimulate corpus luteum to produce progesterone, and the increase of HCG value usually corresponds to the increase of progesterone level. Experimental evidence and clinical experience also support this view.
However, it should be noted that HCG value is only an indicator of progesterone level and cannot be used as the only basis. In the process of IVF, it is also necessary to comprehensively consider other indicators, such as the thickness and quality of endometrium, embryonic development, etc., to comprehensively assess the pregnancy potential of patients.
Therefore, in the process of IVF, monitoring the change of HCG value can be an important auxiliary means to evaluate the progesterone level, but it still needs to be judged in combination with other clinical indicators.
