Failure of IVF
In vitro fertilization (IVF) is a medical method to achieve pregnancy by culturing fertilized eggs in vitro and transplanting them into women's uterus. Although IVF technology has achieved many successful pregnancy cases, there are still some cases where IVF is not successful. This article will elaborate on the failure of IVF from four aspects: embryo quality, endometrial preparation, hormone regulation and psychological pressure.
Embryo quality
Embryo quality is one of the important factors that affect the failure of IVF. During IVF, embryos are cultured in culture dishes, so their quality directly affects the implantation rate. On the one hand, the malformation of embryo morphology may lead to the lack of developmental ability of the embryo, or even the inability to implant; On the other hand, incomplete embryo development will also increase the risk of blastocyst implantation, which will lead to the failure of IVF.
At the same time, the number of embryos will also affect the success rate of IVF. Generally speaking, the more embryos implanted, the higher the implantation rate. Therefore, if the number of embryos implanted is small, the success rate of IVF may be reduced.
In addition, genetic factors of embryos may also lead to the failure of IVF. Some genetic diseases may affect the development ability of the embryo, making it unable to implant successfully.
Endometrial preparation
Endometrial preparation is one of the most important steps in IVF. Factors such as the thickness of endometrium, blood supply and hormone level in endometrium will affect the success rate of implantation.
If the thickness of the endometrium is insufficient, the implantation conditions of the embryo in the uterus will be unsatisfactory, which will lead to the failure of IVF. In addition, insufficient blood supply will also affect the nutrition supply of endometrium and embryo implantation.
The regulation of hormone level is also one of the key factors in endometrial preparation. If there are problems in the process of hormone regulation, such as too much or too little hormone secretion, it may lead to inadequate preparation of the endometrium, thus affecting the success rate of implantation.
Hormonal regulation
Hormone regulation is an essential part of IVF. The natural cycle is simulated by giving the patient progesterone, maintenance hormone and other drugs to regulate the endocrine state of the patient and promote the successful implantation of the fertilized egg. However, there are also some problems that affect the success rate of IVF in the process of hormone regulation.
First, the quality and dosage of hormone drugs have an important impact on the success rate of IVF. If the quality of hormone drugs cannot be guaranteed or the dosage is not accurate, it may lead to abnormal endocrine status of patients, thus affecting the implantation of embryos.
Secondly, adverse reactions during the use of hormone drugs, such as mild nausea, diarrhea, breast distention and pain, will also affect the success rate of IVF. Because these adverse reactions may lead to poor health of patients, thus affecting the implantation of embryos.
Psychological pressure
Psychological pressure during IVF is an important factor that is easy to be ignored. The long-term treatment process, the expectation of pregnancy and the uncertain results have caused great psychological burden to both the husband and wife.
Research shows that excessive psychological pressure will affect the endocrine status, immune function and living habits of patients, thus affecting the success rate of IVF. Therefore, reducing the psychological pressure of patients and maintaining a good attitude are crucial to the success of IVF.
Summary
The failure of IVF mainly involves embryo quality, endometrial preparation, hormone regulation and psychological pressure. The problem of embryo quality may lead to insufficient embryonic development ability or abnormal development, thus affecting the success rate of implantation. Inadequate endometrial preparation, insufficient blood supply and problems in hormone regulation also reduce the success rate of IVF. At the same time, excessive psychological pressure will also affect the patient's physical state and endocrine level, thus affecting the success rate of IVF. Therefore, in the process of IVF, it is necessary to comprehensively consider these factors and take corresponding measures to improve the success rate.
