Causes of IVF failure to meet expectations
The development of IVF technology has enabled many infertile couples to fulfill their dream of becoming parents. However, not all IVF babies can successfully achieve the expected results. The failure of IVF to meet expectations may involve many reasons, which will be described one by one from the aspects of fertilization environment, embryo quality, intrauterine environment and patients' physiological conditions.
Fertilization environment
Fertilization environment is very important for IVF development. The fertilization process of IVF is usually completed in vitro, and then the fertilized eggs are transferred to the mother's uterus. Sometimes, the in vitro fertilization environment cannot completely simulate the natural fertilization environment, resulting in the decline of the quality of the fertilized eggs. On the one hand, there may be harmful substances, such as bacteria or viruses, in the culture medium after fertilization, which will adversely affect the development of the fertilized egg. On the other hand, due to the repeated operation of IVF, the fertilized eggs may be mechanically damaged during the culture process.
In addition, the fertilization environment is also related to the timing of embryo transfer. If the timing of embryo transfer is inappropriate, such as early or late transfer, it may lead to the problem of poor development of IVF. Therefore, it is very important to master the appropriate fertilization environment and embryo transfer opportunity to improve the success rate of IVF.
Embryo quality
Embryo quality is the key to the success of IVF. Embryo quality is mainly related to two aspects: gene problem and embryo development ability problem. In the process of IVF, the quality of fertilized eggs will be affected by many factors, such as the patient's age, lifestyle and disease.
On the one hand, age is one of the important factors that affect the quality of embryos. As women grow older, the quality of eggs will gradually decline, thus affecting the quality of fertilized eggs. In addition, living habits such as smoking, drinking and poor diet will also have a negative impact on the quality of eggs and sperm.
On the other hand, patients with certain diseases, such as polycystic ovary syndrome and endometriosis, may also lead to a decline in the quality of fertilized eggs. These diseases may affect the normal development of eggs and the environment in the uterus, thus affecting the quality of embryos.
Intrauterine environment
The intrauterine environment is crucial for the development of IVF. Abnormal intrauterine environment may lead to poor development of IVF. For example, endometriosis, hysteromyoma and other diseases may lead to the intrauterine environment is not suitable for embryo implantation and development. In addition, the hormone level and immune status of the intrauterine environment will also affect the development of IVF. If the intrauterine environment is abnormal, it may affect the implantation of embryos and the development of prepregnancy embryos.
Physiological condition of the patient
The success of IVF is closely related to the physiological conditions of patients. For example, patients with chronic diseases, such as hypertension and diabetes, may affect the development of embryos and embryo implantation. In addition, patients with immune system diseases, such as systemic lupus erythematosus and myasthenia gravis, may also have adverse effects on the development of IVF.
In addition, semen quality also affects the success rate of IVF. If the quality of male semen is poor, including problems in concentration, vitality and morphology, it may affect the quality of fertilized eggs and the development of IVF.
summary
The failure of IVF to meet expectations may be related to the fertilization environment, embryo quality, intrauterine environment and patient's physiological conditions. Reasonable regulation of fertilization environment and embryo transfer opportunity, improvement of embryo quality, and maintenance of good intrauterine environment and patient physiological conditions will help to improve the success rate of IVF. In case of failure to meet expectations, doctors can make targeted adjustments according to the specific situation and provide further treatment plans.
