Methods to improve the success rate of IVF
The progress of IVF technology has realized the dream for infertile couples. However, the success rate still has some limitations. In order to further improve the success rate, some methods have been adopted by hospitals. The following four aspects will be described in detail, including the improvement of in vitro fertilization technology, embryo quality assessment, drug assisted treatment and assisted reproductive organ transplantation.
1、 Improvement of in vitro fertilization technology
IVF technology is the foundation of IVF success, and its improvement can improve the success rate. The first improvement is to increase the number of eggs collected. The constantly improved ultrasound guided technology and endoscopic technology enable doctors to find more accurately the follicles in the ovary and increase the number of eggs collected. The second method is to improve the quality of eggs and sperm. The use of ovarian stimulators can increase the number and quality of ovulation, thereby increasing the success rate of in vitro fertilization. In addition, ultrasound-guided egg aspiration and sperm injection techniques also significantly improved the fertilization rate.
In addition, embryo culture after in vitro fertilization is also the key to improve the success rate. The traditional culture method is carried out in the medium containing nutrients, but this method cannot provide enough nutrients to maintain the normal development of embryos. Now some hospitals adopt new culture technologies, such as continuous culture or dynamic culture, which can better simulate the intrauterine environment, provide better nutrition and oxygen supply, promote embryonic development, and thus improve the success rate.
2、 Embryo quality assessment
The evaluation of embryo quality is the key to the success of IVF. Accurate evaluation of embryo quality can select the best embryo for transplantation and improve the success rate. A commonly used evaluation method is the embryo appearance scoring method, which evaluates the embryo quality according to the embryo size, cell division degree and cell morphology. However, this evaluation method is subjective and has large errors. At present, some hospitals have introduced genomics, metabonomics and other technologies to assess the health status of embryos and improve the accuracy of embryo quality assessment by detecting the gene expression profile and metabolites of embryos.
In addition, some hospitals also use time lapse embryo monitoring technology during embryo culture to assess embryo quality by continuously monitoring the morphological and dynamic characteristics of embryo development, as well as the potential changes in the embryo intima and other indicators. Using the data and algorithms provided by these technologies, we can accurately assess the potential and health status of embryos, and then select the best embryos for transplantation.
3、 Drug assisted treatment
Drug assisted therapy has played an important role in improving the success rate of IVF. A commonly used drug is ovulation promoting drug, which increases the success rate by improving the development of follicles and increasing the number of eggs collected. In addition, some hospitals also use hormone replacement therapy to regulate the preparation and maintenance of endometrium and increase the success rate of embryo implantation by giving hormone replacement such as estrogen and progesterone.
In addition, some adjuvant drugs can also improve the success rate of IVF. For example, antioxidants can reduce the adverse effects of oxidative stress on the fertilization process and improve the embryonic development environment; Thrombus inhibitor can reduce thrombosis and early abortion rate. The application of these drugs can improve the success rate of IVF.
4、 Assisted reproductive organ transplantation
Some IVF hospitals also tried assisted reproductive organ transplantation to improve the success rate. For example, uterine transplantation can enable women without uterus to realize their dreams of childbirth; Testicular transplantation can make men without sperm achieve fertility. Although these organ transplantation operations are technically complex, they provide the possibility of increasing the success rate of IVF for some specific patients.
Summary
In order to improve the success rate of IVF, the hospital has made efforts in many aspects, such as in vitro fertilization technology improvement, embryo quality assessment, drug assisted treatment and assisted reproductive organ transplantation. Improving in vitro fertilization technology and embryo culture method can improve fertilization rate and embryo development quality; Accurate evaluation of embryo quality can select the best embryo for transplantation; Drug assisted therapy can promote the healthy development of eggs and embryos; Assisted reproductive organ transplantation can provide fertility for certain patients. The continuous improvement and application of these methods provide a broader prospect for the success rate of IVF.
