How to judge the embryo quality of IVF?
The technology of IVF has become a focus in the field of reproductive medicine, and embryo quality is one of the important factors affecting the success rate of IVF. For the evaluation of embryo quality, the medical community usually conducts a comprehensive evaluation from the following aspects.
Embryo cell segmentation
The normally developing embryo will go through different cell division stages, such as the fertilized egg progressing to two cell, four cell, six cell and other stages. The division of embryonic cells is one of the important indexes to evaluate the quality of embryos. Generally, embryos can be divided smoothly at a predetermined time and form regular cell populations. If it is found that the embryo develops slowly or has abnormal segmentation at a specific stage, it may mean that its quality is poor.
In addition, the segmentation uniformity of embryos is also one of the important indicators to evaluate the quality of embryos. The normal embryo cells are evenly divided and the cell size is similar; However, embryos with poor quality may have problems such as uneven cell size and abnormal cell number.
It is worth mentioning that the cell division of the embryo is observed through a microscope and needs to be judged by trained medical personnel.
Chromosome detection of embryos
Chromosome abnormality is one of the important reasons for embryo implantation failure, abortion, abnormal fertility and other problems. At present, chromosome detection technology has been widely used in the embryo quality evaluation of IVF.
Common chromosome detection methods include first generation sequencing (PGS) and sperm chromosome screening (SCSA). These methods can detect whether the embryo carries chromosome abnormalities, and then evaluate the embryo quality. Embryos with normal karyotype have a higher probability of successful development and implantation, while embryos with chromosome abnormalities have a risk of development and implantation obstacles.
However, the relationship between specific chromosomal abnormalities and the success rate of IVF needs further research and verification.
Evaluation of embryo internal structure
In addition to chromosome testing, doctors also evaluate the quality of an embryo by observing its internal structure. The commonly used evaluation methods include the amount and quality of fluid in the blast cell cavity, the tightness of embryonic cells, etc.
The amount and quality of fluid in the embryo cell sac can reflect the health of the embryo. The fluid in the cell sac of normal embryos is abundant and the quality of the fluid is uniform. However, embryos with poor quality may have uneven fluid in the cyst cavity, too much or too little fluid in the cyst cavity, etc.
In addition, the compactness of embryonic cells is also one of the bases for evaluating embryo quality. Normal embryonic cells are densely arranged and orderly, and the cell quality is uniform; However, poor quality embryos may have loose cells or cell aggregation.
Morphological characteristics of embryos
Finally, the morphological characteristics of embryos are also one of the important bases for judging the quality of embryos. Normal embryos have good morphological structure, including cell symmetry, cell membrane integrity, etc. Doctors can preliminarily assess the health of an embryo by observing whether it has the correct shape characteristics.
It should be noted that although these assessment methods can provide reference, they cannot completely predict the development and implantation of embryos. The evaluation of embryo quality still needs to comprehensively consider multiple factors, and professional doctors should make comprehensive judgments based on clinical experience and actual conditions.
Summary
In a word, the evaluation of IVF embryo quality is generally considered from the aspects of embryo cell segmentation, embryo chromosome detection, embryo internal structure evaluation and embryo morphological characteristics. These evaluation indicators reflect the health status and development potential of embryos to a certain extent, and help to improve the success rate of IVF. However, embryo quality evaluation still needs individualization, comprehensive consideration, and further research and verification.
