Technological innovation of the third generation of IVF
Since the birth of IVF technology in the 1970s, it has experienced many technological innovations and breakthroughs, and the third generation IVF technology is increasingly developing and improving. This article will introduce the technological innovation of the third generation of IVF from four aspects.
1. Progress in embryo screening
Embryo screening is an important part of IVF technology. Genetic testing of fertilized eggs can eliminate or reduce the risk of chromosomal abnormalities and genetic diseases, and improve the fertility success rate. The innovation of the third generation IVF technology in embryo screening is mainly reflected in the following aspects.
First, the application of a new generation of high-throughput sequencing technology makes embryo screening more accurate. Taking a regular hospital in China as an example, they introduced the PGD system of Yuhua Medical Technology Co., Ltd. Through high-throughput sequencing analysis, thousands of gene mutations can be detected simultaneously, greatly improving the accuracy of screening.
Secondly, the third generation IVF technology introduced methylation detection technology in embryo screening. Methylation is a regulation mechanism of gene expression, which is very helpful for screening the activity of genes related to some genetic diseases. The practice of a hospital shows that methylation detection technology can effectively screen out some gene defects, thus avoiding embryo transfer failure.
In addition, the third generation IVF technology also introduced non-invasive gene detection technology in embryo screening. Traditional embryo screening methods need to take out one or more cells for detection, which may cause damage to the embryo. The non-invasive gene detection technology detects the free embryo DNA in the embryo culture medium, without invasive operation on the embryo, which is safer and non-invasive.
2. Improvement of in vitro embryo culture
In vitro embryo culture is one of the key steps in IVF technology, which affects the quality and development potential of embryos. The innovation of the third generation IVF technology in vitro embryo culture mainly includes the following points.
First, the third generation IVF technology has improved the formula of embryo culture medium. Due to the difference between in vitro culture conditions and uterine environment, some components in traditional culture medium may affect embryonic development. Therefore, a hospital began to use culture medium with fine regulation of cytokines and nutrients to improve the survival rate and quality of embryos.
Secondly, the third generation IVF technology has introduced a dynamic culture system. The traditional embryo culture system is static and cannot simulate the dynamic changes of the uterine environment. The dynamic culture system can provide appropriate nutrients and gas supply according to the needs of embryos, thus improving the development of embryos.
In addition, the third generation IVF technology has also introduced three-dimensional culture technology into in vitro embryo culture. Embryos cultured in a three-dimensional environment can better simulate the growth environment in the uterus, provide better support and protection, and help improve the survival rate and development potential of embryos.
3. The rise of blastocyst transfer
Blastocyst transfer refers to the transfer of embryos at the blastocyst stage, which has a higher success rate and implantation rate. The innovation of the third generation IVF technology in blastocyst transfer is mainly reflected in the following aspects.
First, the third generation IVF technology has greatly improved the blastocyst culture rate. The culture rate of traditional IVF technology from embryo development to blastocyst stage is low, only about 30%. By optimizing the culture conditions and using new culture medium, the practice result of a hospital shows that the blastocyst culture rate has reached more than 70%.
Secondly, the third generation IVF technology introduced the embryo chromosome assessment before embryo implantation. Chromosome evaluation of blastocysts can eliminate the transfer of embryos with chromosomal abnormalities, and improve the success rate of transfer and pregnancy rate.
In addition, the third generation of IVF technology introduced the technology of embryo poverty alleviation in blastocyst transfer. Embryo anti-poverty technology can draw out the anti-poverty sac fluid in the blastocyst in advance, which can reduce the risk of embryo anti-poverty and improve the success rate of transplantation.
4. Comprehensive application of the first generation IVF technology
The third generation IVF technology has further improved the success rate of IVF and the accuracy of genetic disease screening through the comprehensive application of various technical means.
For example, a hospital adopted PGD technology combined with in vitro embryo culture improvement and blastocyst transfer technology, successfully carried out genetic disease screening and survival of the fittest, improving the fertility success rate.
In a word, the third generation IVF technology has made important technological innovations in embryo screening, in vitro embryo culture, blastocyst transfer and comprehensive application. These innovations not only improve the fertility success rate of IVF, but also reduce unnecessary embryo transfer and genetic disease risks, bringing more hope and options to infertile patients.
