What should we pay attention to in vitro infant protocol antagonists?
In vitro fertilization (IVF) is a method to help infertile couples realize their reproductive dreams by cultivating the fertilized eggs to an appropriate level of embryonic development and then implanting them into the mother's uterus. In the process of IVF, the use of drugs plays a key role. Antagonists are commonly used drugs, which are very important in controlling female ovulation cycle and optimizing the process of IVF. The following will elaborate on the precautions of IVF protocol antagonists from four aspects: dose, time point of use, side effects and drug monitoring.
dose
The dose of antagonist is crucial to the success rate of IVF. If the dose is too high, it will inhibit the secretion of luteinizing hormone (LH) in women, and then inhibit the development of follicles, leading to the failure of IVF. If the dosage is too low, the secretion of luteinizing hormone cannot be effectively inhibited, and the follicles are discharged too early, which affects the quality of fertilized eggs. Therefore, when using antagonists, it is necessary to adjust the precise dosage according to women's individual conditions, follicular development, drug sensitivity and other factors. Generally speaking, if the dose is too high, it should be reduced in time, and if the dose is too low, it should be increased appropriately.
In addition, in the process of dose adjustment, it is necessary to regularly monitor the size and number of follicles, the level of luteinizing hormone in the blood, and the endocrine status of women. This can be done through transvaginal ultrasound examination, endocrine indicators detection and other methods to ensure the reasonable adjustment of the dose and improve the success rate of test tube babies.
Use time point
The timing of the use of antagonists in IVF programmes is also important. In general, when the follicles develop to a certain extent, in order to avoid the flooding of luteinizing hormone and premature rupture of follicles, antagonists should be used. Usually, when the follicle diameter reaches 18-20 mm, the drug is started. This time point is usually in the middle and late stages of follicular development. At this time, the antagonist can effectively inhibit the secretion of luteinizing hormone, so that the follicles do not rupture in advance.
However, early or late use of antagonists may have adverse effects on the IVF process. Therefore, it is very important to accurately judge the follicular development and select the appropriate time point for use. In order to ensure the accuracy of the time point of use, doctors usually conduct regular inspections according to the development of follicles, such as salpingography, blood hormone detection and vaginal ultrasound.
side effect
Antagonists, as a kind of medicine, may have side effects during use. Common side effects include headache, breast pain, mood fluctuation, nausea and abdominal distension. These side effects are generally temporary and will not have a long-term impact on health. However, in case of severe allergic reaction, dyspnea, severe bleeding or infection during use, seek medical advice immediately.
In addition, antagonists have certain effects on hormone levels in women's bodies, which may lead to ovarian function depression and the risk of ovarian hyperstimulation syndrome (OHSS). Therefore, when using antagonists, doctors need to closely monitor hormone levels and follicular development to ensure that the dose is appropriate to avoid the occurrence of OHSS.
Medication monitoring
The use of antagonists requires close drug monitoring. This includes monitoring of follicular development, hormone levels and endocrine status. In the course of medication, doctors need to conduct transvaginal ultrasound examination to observe the size and number of follicles and the thickness of endometrium. In addition, through blood hormone detection, doctors can understand the changes in hormone levels and adjust the dose.
Monitoring can find and solve problems in the process of drug use in a timely manner to ensure the smooth implementation of the IVF program. Therefore, the hospital needs to establish a perfect monitoring system and equip professional testing equipment and technicians when carrying out the IVF program.
Summary
Antagonists in IVF protocol play an important role in controlling female ovulation cycle and optimizing IVF process. When using antagonists, it is necessary to pay attention to the accurate adjustment of dosage, appropriate use time, timely monitoring of side effects and drug effects, and close drug use monitoring. Only by paying attention to these points can we ensure the success rate and safety of IVF program. Therefore, when selecting hospitals and experts, we need to consider the drug use monitoring system of hospitals and the experience and technical level of professionals.
