Causes of IVF abortion
IVF technology is an assisted reproductive technology, which can help couples who cannot conceive naturally due to physiological reasons to achieve their reproductive aspirations. However, IVF pregnancy is often accompanied by the risk of abortion. The following will elaborate on why IVF is prone to abortion from several aspects.
Effects of in vitro fertilization on embryos
In vitro fertilization (IVF) is the core process of IVF, which involves the combination of eggs and sperm in the laboratory. In this process, the embryo may be damaged to some extent or affected by unstable factors. First of all, the IVF process of IVF may lead to damage to the embryo, for example, manipulation of eggs and sperm may lead to the destruction of embryonic cells. Secondly, embryos grow in the environment of in vitro culture, which is different from the internal environment, and may have adverse effects on embryo development. These unstable factors will increase the risk of abnormal embryonic development and abortion.
In addition, IVF is not 100% successful, and its success rate is generally between 30% and 50%. This means that even if the embryo is successfully implanted into the mother's uterus, it may also cause abortion due to abnormal embryonic development and other reasons. In addition, in the process of IVF, multiple embryos are usually implanted to improve the probability of pregnancy, but it will also increase the risk of multiple pregnancy, thus further increasing the possibility of abortion.
Effect of hormone therapy on pregnancy
In the process of IVF, hormone therapy is often needed to promote the development of eggs and the secretion of progesterone, while maintaining the normal progress of pregnancy. However, the use of these hormones may have a negative impact on pregnancy and increase the risk of miscarriage.
First, ovarian hyperstimulation therapy may lead to ovarian hyperstimulation syndrome (OHSS), because excessive hormone stimulation of the ovary leads to ovarian swelling and fluid accumulation. OHSS will increase the risk of miscarriage in early pregnancy. Secondly, progesterone is an important hormone to support pregnancy, and the level of progesterone in IVF may be affected by manual intervention. If the progesterone level is unstable or lower than the normal level, the embryo is easy to lose in the implantation and early pregnancy.
Influence of intrauterine environment
Not all processes of IVF are carried out in the laboratory, and embryos often need to be transferred to the mother's uterus for further development. However, this link may also have adverse effects on the survival of embryos.
First, the quality and thickness of endometrium will affect the success rate of implantation. In the process of IVF, the endometrium is embedded after controlled proliferation, but not every IVF patient's endometrium can reach the ideal state. When the quality of endometrium is poor and the thickness is not enough, it will affect the implantation and development of embryos and increase the incidence of abortion. Secondly, abnormal uterine structure such as hysteromyoma and gynecological diseases such as endometriosis will also have a negative impact on pregnancy and increase the risk of abortion.
Physical and genetic factors of both spouses
The causes of IVF abortion are also related to the physical and genetic factors of both spouses. On the one hand, women are more likely to choose IVF due to reproductive system problems, and women's own physiological conditions may increase the risk of abortion. For example, the aging of women will lead to the decline of egg quality and increase the risk of abnormal embryonic development and abortion. On the other hand, because of sperm quality problems, men may need to use IVF technology to achieve fertility, and poor sperm quality will also increase the probability of pregnancy and abortion.
Summary
There are many reasons why IVF babies are prone to miscarriage. In terms of the influence of IVF technology on embryos, the influence of hormone therapy on pregnancy, the influence of intrauterine environment, and the physical and genetic factors of both spouses, the risk of IVF abortion will increase. Therefore, for IVF patients, doctors need to consider these factors comprehensively and take appropriate measures to reduce the risk of abortion and improve the probability of IVF success.
