Causes of high sperm abnormality rate in test tube infants
IVF is an assisted reproductive technology, which helps infertile couples realize their reproductive dreams through in vitro fertilization. However, some IVF babies have high sperm malformation rates, which may lead to difficulties in fertilization or abortion. The following will analyze the reasons for the high sperm abnormality rate of IVF from four aspects.
1. Abnormal reproductive system
The high rate of sperm deformity may be due to the abnormality of the father's reproductive system. Reproductive system abnormalities may include testicular development disorder, vas deferens blockage, seminal vesicle infection and other problems. These abnormal conditions will have adverse effects on spermatogenesis and maturation process, leading to sperm morphology distortion.
Some men may be born with reproductive system abnormalities, which may be caused by chromosome abnormalities, gene mutations or other genetic factors. If these abnormalities are not detected and treated in time, it may increase the sperm abnormality rate of IVF.
In addition, some external factors can also have adverse effects on the male reproductive system, such as long-term exposure to environmental pollutants, radiation or chemicals, or a long history of taking certain drugs. These factors will interfere with the formation and maturation of sperm, thus leading to the increase of sperm deformity rate.
2. Genetic factors
Genetic factors are also an important reason for the high sperm malformation rate of IVF. Some men may carry gene mutations of some hereditary sperm abnormalities, which may directly affect the normal development of sperm morphology.
These gene mutations may be generated during the formation of germ cells or inherited from parents. If at least one parent carries an abnormal gene, their children may also carry the gene and show sperm abnormalities.
Hereditary sperm malformation may take different forms, such as tail malformation, head malformation or irregular shape. These malformations will affect the motility and fertilization ability of sperm, which will lead to an increase in the sperm malformation rate of IVF.
3. Age factor
The age of men also has a certain impact on sperm deformity rate. With the growth of age, male germ cells may be damaged cumulatively, thus increasing the risk of sperm abnormalities.
The study found that the sperm quality of men decreased with age, and the sperm deformity rate also increased. This may be related to the accumulation of DNA damage in germ cells and the increased risk of chromosomal abnormalities.
Therefore, if couples with high sperm abnormality rate of IVF are older, they need to pay more attention to this problem, and fully consider the influence of male age on sperm quality in the treatment plan.
4. Other environmental factors
In addition to the above factors, environmental factors may also have an impact on the sperm abnormality rate of IVF. Environmental factors include lifestyle, eating habits, exposure to chemicals, etc.
Poor lifestyle and eating habits may lead to malnutrition, obesity, alcohol and drug abuse and other problems, thus affecting the formation and development of sperm. Exposure to chemicals such as pesticides, heavy metals and other environmental pollutants may also have adverse effects on sperm quality.
Therefore, IVF couples should try their best to improve their lifestyle, maintain good eating habits, avoid bad working environment and exposure to harmful substances, so as to reduce the risk of sperm malformation rate.
summary
The high sperm malformation rate of IVF may be due to the combined effects of reproductive system abnormalities, genetic factors, age factors and other environmental factors. Understanding and identifying these potential problem factors is very important for improving the success rate of IVF and giving birth to healthy babies. Scientific evaluation and treatment plan will help to reduce the sperm abnormality rate and provide better conditions for the success of IVF.
