Effect of ovarian dysfunction on the success rate of IVF
IVF technology is an assisted reproductive technology that fertilizes eggs and sperm in vitro, which can help couples who cannot conceive naturally due to physiological reasons realize their reproductive dreams. However, ovarian dysfunction is a common gynecological disease, which will have a certain impact on the success rate of IVF. The following four aspects of ovarian hormone secretion, egg quality, fertility and transplantation adaptability are described in detail.
1. Ovarian hormone secretion
Ovarian dysfunction refers to premature ovarian failure or low ovarian function, which will lead to insufficient or imbalance of ovarian hormone secretion. Ovarian hormones are essential for normal ovarian function and embryo implantation and development during pregnancy. The loss of ovarian function will lead to the reduction of ovarian hormone secretion, which will affect the development and quality of eggs and reduce the success rate of IVF.
In addition, the lack of ovarian function may also lead to luteal insufficiency and insufficient secretion of progesterone. Progesterone is an important hormone for embryo implantation and fixation, which is critical for embryo implantation and normal development of early embryos. Therefore, ovarian dysfunction will affect the secretion of progesterone, increase the risk of early abortion, and reduce the implantation rate of IVF.
2. Egg quality
The loss of ovarian function will affect the quality of eggs. Premature ovarian failure or low function will reduce the number of eggs and accelerate the aging process of eggs. The quality of aging eggs is poor, and the ability of fertilization and embryo development is poor, thus reducing the success rate of IVF.
In addition, the loss of ovarian function may be accompanied by the increase of chromosome abnormalities, such as chromosome number abnormalities, structural abnormalities, etc. These chromosomal abnormalities will increase the risk of abnormal embryonic development, leading to an increase in the abortion rate of IVF.
3. Incubation capacity
Lack of ovarian function may lead to irregular menstruation and even amenorrhea. The instability or absence of menstrual cycle means that the chance of ovulation is reduced, leading to a reduced chance of pregnancy. In addition, ovarian dysfunction may be accompanied by endometrial abnormalities, such as insufficient or thin conditions. This will affect the implantation and fixation of embryos and reduce the success rate of IVF.
In addition, the loss of ovarian function may be accompanied by an increase in androgen levels. Excessive androgen will inhibit the development of eggs and hormone secretion, and interfere with the normal pregnancy process.
4. Transplantation adaptability
The lack of ovarian function may lead to the maladjustment of the uterine environment. Endometrium plays an important role in the process of IVF embryo transfer. Lack of ovarian function will lead to abnormal thickness, quality and hormone secretion of endometrium, which will affect the implantation and development of embryos. Therefore, the loss of ovarian function will reduce the adaptability and success rate of IVF embryo transfer.
summary
Ovarian dysfunction has a significant impact on the success rate of IVF. From the analysis of ovarian hormone secretion, egg quality, fertility and transplantation adaptability, it can be seen that ovarian dysfunction will affect the development and quality of eggs, increase the risk of abortion and reduce the success rate of IVF. At the same time, ovarian dysfunction may also affect the endometrium and individual androgen levels, further affecting the implantation and fixation of embryos. Therefore, patients with ovarian dysfunction should be comprehensively evaluated and treated under the guidance of doctors to improve the success rate of IVF.
