The choice of drugs for lowering the tone of test tube infants
IVF refers to the embryo obtained in vitro culture through assisted reproductive technology, and then implanted into the mother's uterus to develop into a baby. In the process of IVF, reducing the activity of maternal immune system is an important measure. Next, we will introduce the drug selection of IVF from the perspective of drug selection.
Drug targets
In the process of IVF, the rejection of embryo by maternal immune system is an important factor affecting the success of pregnancy. Therefore, the choice of drugs should be able to inhibit the activity of the maternal immune system and reduce the immune rejection of embryos. At the same time, drugs should be safe, reliable, and able to effectively achieve the goal of lowering the tone.
At present, the commonly used down-regulation drugs are glucocorticoids, immunosuppressants, etc. Among them, glucocorticoid is the most widely used, and the commonly used drugs are prednisone, dexamethasone, etc.
Drug dose and cycle
The dosage and cycle of glucocorticoid should be determined according to individual conditions. Generally speaking, short-term use of prednisone or dexamethasone can reduce the activity of maternal immune system and reduce the immune rejection of embryos. The dosage is generally 20-40 mg prednisone or 0.5-1.5 mg dexamethasone per day, and the medication cycle is usually 8-14 days before the start of the IVF cycle.
In addition, immunosuppressive drugs can also be used as one of the choices of down-regulation drugs. The dosage and cycle of immunosuppressive drugs should also be determined according to individual conditions. Common immunosuppressants include cyclosporine A, tacrolimus, etc. The dosage and use cycle need to be adjusted according to the doctor's guidance.
Adverse drug reactions and risks
The use of down-regulation drugs will also bring certain adverse reactions and risks. When glucocorticoid is used for a short time, the common adverse reactions include side effects of cardiovascular system, metabolic system and immune system. Long term use of glucocorticoid may cause more adverse reactions, such as osteoporosis, gestational diabetes, etc. The use of immunosuppressants may lead to low immune function and increase the risk of infection and malignancy. Therefore, in the process of using down-regulation drugs, we should work closely with doctors to regularly monitor the efficacy and adverse reactions of drugs.
Summary
The choice of drugs for IVF down-regulation is a process that comprehensively considers individual conditions and drug characteristics. Common down-regulation drugs include glucocorticoids and immunosuppressants. The use of these drugs can reduce the activity of the maternal immune system and reduce the immune rejection of embryos. However, drug use will also bring certain adverse reactions and risks, which need reasonable guidance and monitoring by doctors. In practice, rational medication should be used according to individual conditions to ensure the successful pregnancy of IVF.
